Mirtazapine reduces social anxiety and improves quality of life in women with social phobia.

MAIN RESULTS At 10 weeks, mirtazapine improved symptoms of social anxiety compared with placebo in women with social phobia (difference in score change between mirtazapine and placebo: SPIN 8.1, 95% CI 29.6 to 4.1; p,0.001; LSAS 220.2, 95% CI 227.5 to 24.1; p,0.001 ). Mirtazapine also improved general health perceptions, vitality, social functioning, and mental health, and reduced role limitations due to emotional problems (p,0.001 for all; see http://www.ebmentalhealth.com/supplemental for table). There was no significant difference between mirtazapine and placebo in the physical aspects of quality of life (p.0.05; see http://www.ebmentalhealth.com/ supplemental for table).